David Ortiz was placed on the 15-day disabled list Wednesday with an injured Achilles tendon.
Veteran right-hander Justin Germano, who was designated for assignment earlier this week, is purchased by Chicago.
Dustin Pedroia will start at second base and hit third Thursday in his first game since July 3.
It was a tough start to the David OrtizDL Era, but with Jacoby Ellsbury and Carl Crawford playing well, maybe the Sox will be all right after all.
The Red Sox crushed the White Sox 10-1 Wednesday, allowing starter Felix Doubront to improve his record to 10-4.