The New England Revolution get back to work on Saturday night, following a scoreless draw last weekend at home against the Columbus Crew.
They'll travel to Canada to take on Toronto FC, the last-place team in the Eastern Conference.
Toronto has the least amount of points in the MLS, with just four, on a 1-10-1 record. The Revs, meanwhile, enter Saturday's match as the seventh-place team in the East (out of 10), with 17 points, on a 5-7-2 record.
Unfortunately for New England, it is winless with an 0-2-3 record at BMO Field. It's one of only two MLS venues in which the Revolution have visited five times without a win.
If they want to break that streak on Saturday night in Toronto, the Revs will have to do it without their captain, Shalrie Joseph, who will miss the game with an adductor strain that he suffered last weekend against Columbus.
Also out for Saturday's match is forward Jose Moreno, who left last weekend's game against the Crew with a sprained left ankle.
Nemanja Nikolic and Luis Solignac scored and the Chicago Fire handed the New England Revolution their first home loss of the season, 2-1 on Saturday night.
Nikolic scored his MLS-leading 13th goal in the 18th minute, beating an offside trap and, after having his initial shot blocked by goalie Cody Cropper, firing in the rebound.
Three quick passes found Solignac in front of the goal as he finished from close range in the 61st for his fourth goal.
New England scored in the 70th when Juan Agudelo kept the ball alive with a header off a cross with Antonio Mlinar Delamea then heading in the ball for his first MLS goal.
New England, which outshot Chicago 24-8, spent the remaining minutes on the attack but failed to get the equalizer despite several frantic moments in front of Chicago's net.
New England (5-6-5) had five wins and two draws at home before the loss. Chicago (9-3-4) is unbeaten in eight matches.
Jay Heaps talks with Brad Feldman and Paul Mariner about the preparation and gameplan that the players bought into that gave the Revs the win.