GAME TIME: 4:25 p.m. EST
TV NETWORK: CBS
TV ANNOUNCERS: Ian Eagle and Dan Fouts
RADIO NETWORK: Anchored by WBZ-FM (98.5 The Sports Hub)
RADIO ANNOUNCERS: Bob Socci and Scott Zolak
ALL-TIME SERIES BETWEEN THE TEAMS: Patriots lead, 65-41-1
LAST MEETING: Patriots 23, Bills 21 on Sept. 8, 2013 at Ralph Wilson Stadium
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-- The Patriots will clinch a first-round playoff bye with a victory. They can also clinch a first-round bye if both the Bengals and Colts lose. The Patriots can clinch the No. 1 seed in the AFC, and home-field advantage throughout the playoffs, with a victory and a Broncos loss.
-- A first-round bye would be the Patriots' eighth since 2001, the most in the NFL. The Bears and Steelers are second during that time with four byes, and neither will earn a first-round bye this year.
-- The Patriots are 7-0 at home in 2013 and will attempt to finish a perfect 8-0 at Gillette Stadium for the sixth time in team history. New England also finished perfect at home in 2003, '04, '07, '09 and '10. The only other teams undefeated at home in 2013 are the Bengals and Saints.
-- The Patriots are opening and closing the season against the Bills. They did that once before, in 2003, and won the Super Bowl that year.
-- The Patriots have won their last 12 games in Foxboro against Buffalo, and are a perfect 11-0 vs. Buffalo at Gillette Stadium since the stadium opened in 2002.
-- Tom Brady is 21-2 against the Bills, the most regular-season games he has won against any opponent. He has also thrown for more touchdowns (53) against Buffalo than any other team, and has more 300-yard games (7) against Buffalo than any other team.
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WHAT TO LOOK FOR
-- Bill Belichick will be looking to record a 12th win in a season for the eighth time as head coach of the Patriots.
-- Danny Amendola (624) needs 66 yards against Buffalo to set a new single-season career high, surpassing the 689 yards he had in 2010.
-- Stephen Gostkowski (34) needs two more field goals to match his franchise record of 36, set in 2008,
-- Brady (147) needs one more win to break a tie with Dan Marino and move into sole possession of third place for most wins in NFL history by a starting quarterback. Brett Favre (196) is first and Peyton Manning (166) is second.
-- Brady (366) needs 34 completions to reach 400 completions for the season. Drew Brees (5), Brady (2) and Manning (2) are the only players to have at least two seasons with 400 completions.
-- Julian Edelman has 96 receptions and needs four more to join Wes Welker (2007, '08, 09, '11, '12) and Troy Brown (2001) as the only Patriots players to reach 100 receptions in a season. Edelman is averaging 6.4 receptions per game in 2013. - The Patriots are looking for their 15th straight regular-season home win against an AFC East opponent. They have not lost a regular-season game to an AFC East team at Gillette since falling to the Jets, 34-31 in overtime, on Nov. 13, 2008. (The Pats lost to the Jets in the 2010 playoffs at Gillette.)