BOSTON -- After being held scoreless for the previous eight innings, the Red Sox finally snapped to life in the 12th inning, securing just their second walkoff win of the season and second extra-inning victory, edging the Cincinnati Reds, 4-3 on a single off The Wall from Grady Sizemore.
David Ortiz led off with a single and took second when Mike Napoli drove a single up the middle. Sizemore, who nearly signed with the Reds before coming to Boston, then came through with the game-winner for his first walk-off hit since Aug. 11, 2006.
Koji Uehara had to wiggle out of a ninth-inning jam when Zack Cosart reached on an infield hit, took second on a sacrifice and moved to third on a flyout to the warning track in right.
But Uehara got Joey Votto on a pop foul to third, preserving the tie.
The Sox seemed in command with a 3-1 lead after seven, but the Reds got to Junichi Tazawa with two runs in the eighth.
A one-out walk to Joey Votto, a double down the left field line from Brandon Phillips, a single to left by Todd Frazier and a sacrifice fly to right from Ryan Ludwick produced the two runs.
Boston had used a groundout and a bases-loaded walk to go along with a run-scoring single from Grady Sizemore to account for its three runs -- all scored in the first three innings.
Felix Doubront alternated between efficient 1-2-3 innings and more drawn-out, pitch-filled frames and after issuing walks to two of the first three batters he faced in the sixth, was finished.
The win was the first in four tries in interleague play for the Red Sox, who were swept by Milwaukee in their only other series against National League opponents this season.
STAR OF THE GAME: Grady Sizemore
Sizemore had a three-hit night, but none was bigger than his single off The Wall in the bottom of the 12th inning, scoring David Ortiz from second base to give the Red Sox a 4-3 win. Sizemore had also driven in a run in the third with another single.
HONORABLE MENTION: Andrew Miller
While the Red Sox offense stagnated, Miller kept buying the Red Sox time with two dominant innings of relief, during which he struck out four of the seven batters he faced. The only baserunner who reached against him was on base thanks to an error.
GOAT OF THE GAME: Logan Ondrusek
After a scoreless 11th inning, Ondrusek faced three batters in the 12th and gave up three hits - including Sizemore's game-winner.
TURNING POINT: Koji Uehara got himself into - and then out of - trouble in the ninth. With runners on first and third, he got Joey Votto to pop-up to third base, stranding two.
BY THE NUMBERS: In 13 at-bats with runners in scoring position, the Red Sox collected just two hits -- both by Sizemore, including the walk-off single in the 12th.
QUOTE OF NOTE: "I wanted to be ready early and I got a fastball, first pitch, and decided to jump on it.'' Grady Sizemore on his 12th inning heroics.