Hunter is vying to replace closer Jim Johnson, who was traded during the offseason. Hunter has pitched three innings this spring training and yielded two runs - both on homers by Middlebrooks.
This time, Middlebrooks pounced on Hunter's first pitch to put Boston up 3-2. A.J. Pierzynski followed with a single but Hunter avoided further damage.
Holt homered in the third off Miguel Gonzalez, who was struck in the shin by a line drive in his previous outing.