TORONTO -- The Red Sox didn't get a hit from the first batter of the game until two were out in the ninth inning and were shut out for the first time this season.
And that was far from the worst news of the day for the Sox.
In the middle of their 5-0 loss to the Toronto Blue Jays in which they mustered just one hit, the Red Sox lost starter John Lackey to a biceps strain in the fifth inning.
Lackey bounced a pitch inside and in the dirt to Jose Reyes with one out in the fifth and immediately grabbed his right biceps. He left the game a minute later, his right arm hanging limp at his side.
He was making his first start since September of 2011 after undergoing Tommy John surgery in October of that year and had pitched brilliantly, striking out eight in 4 1/3 innings while allowing two runs on a homer by catcher J.P. Arencibia.
Alfredo Aceves took over for Lackey and pitched the rest of the way, allowing a three-run homer to Colby Rasmus in the sixth to account for the other three Toronto runs.
J.A. Happ gave up a double to Jacoby Ellsbury to start the game, then didn't allow another hit over the next 5 1/3 innings. Steve Delabar, Aaron Loup and Sergio Santos followed Happ and helped complete the shutout.
The only other hit came on a two-out single to the shortstop hole by Dustin Pedroia with two down in the ninth.
Both Red Sox losses this season have come against lefthanded starters. The team was beaten by Andy Pettitte of the New York Yankees Thursday night.
STAR OF THE GAME: J.A. Happ
Happ went 5 1/3 innings of shutout ball and allowed just one hit -- a double to Jacoby Ellsbury -- to start the game. Happ walked three and struck out six, successfully working out of a first-and-second, two-out jam in the third.
HONORABLE MENTION: J.P. Arencibia
The Toronto catcher got ahold of a cutter from Lackey and smashed a two-run homer in the fourth inning that would be all the offense the Jays would need.
GOAT OF THE GAME: Dustin Pedroia
Pedroia had two chances with runners in scoring position early in the game and couldn't deliver. He took a called third strike to end the first with Ellsbury on third, then popped up with two on for the final out in the third.
TURNING POINT: Given that the Red Sox went from the first batter until the next-to-last without a hit, they were never really in the game. That makes Arencibia's two-run homer in the fourth the key.
BY THE NUMBERS: Shane Victorino (walk) has reached safely in all five games to date.
QUOTE OF NOTE: "Oh, God.'' Clay Buchholz, asked his reaction in the dugout when he saw John Lackey grab his right arm.